Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS020)
PSS Name
Centyrin
Synonyms
Tenascin C-based binder
Diagrammatic Sketch
Highest Status Research
Class Non-Antibody
Fold Type Beta-Sheets + Loops
Thermal Denaturation TEMP 46-87℃
Sequence Length 89-103
Molecular Weight 9-12 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Fibronectin(type III) domains of Tenascin C Fn3
3TES
Q90484
Human
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Centyrin anti-Fc-gamma-RII S29 Research Antibody SF2 Expi293F human cells CIS display
SBP Info
 		[1]
Centyrin anti-HGFR P114-A3 Research Tencon Escherichia coli CIS display
SBP Info
 		[2]
Centyrin anti-IL-17A TP1-C6 Research Tencon Escherichia coli CIS display
SBP Info
 		[2]
Centyrin anti-Leukocidin/Toxin-HlgA SM1S449 Research Tencon Escherichia coli CIS display
SBP Info
 		[3]
Centyrin anti-Leukocidin/Toxin-HlgA SM1S452 Research Tencon Escherichia coli CIS display
SBP Info
 		[3]
Centyrin anti-leukocidins SM1S163 Research Tencon Escherichia coli CIS display
SBP Info
 		[3]
Centyrin anti-leukocidins SM1S17 Research Tencon Escherichia coli CIS display
SBP Info
 		[3]
Centyrin anti-leukocidins SM1S26 Research Tencon Escherichia coli CIS display
SBP Info
 		[3]
Centyrin anti-TNF-alpha P191-22 Research Tencon Escherichia coli CIS display
SBP Info
 		[2]
Centyrin anti-ERBB1 83v2 variant Research Centyrin 83v2 Escherichia coli BL21 (DE3) N.A.
SBP Info
 		[4]
Centyrin anti-ERBB1 83v2 Research N.A. Escherichia coli N.A.
SBP Info
 		[4]
References
1 FcRII-binding Centyrins mediate agonism and antibody-dependent cellular phagocytosis when fused to an anti-OX40 antibody. MAbs. 2018 Apr;10(3):463-475.
2 Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions. Protein Eng Des Sel. 2014 Oct;27(10):419-29.
3 Identification of biologic agents to neutralize the bicomponent leukocidins of Staphylococcus aureus. Sci Transl Med. 2019 Jan 16;11(475):eaat0882.
4 Engineering a targeted delivery platform using Centyrins. Protein Eng Des Sel. 2016 Dec;29(12):563-572.