Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000414)
SBP Name	Centyrin anti-IL-17A TP1-C6
Synonyms	Centyrin TP1-C6
Molecular Weight	9.6 kDa
Thermal Denaturation TEMP	45.6-87.3 ℃
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli
Selection Method	CIS display
Highest Status	Research
Sequence Length	89
SBP Sequence	>Centyrin anti-IL-17A TP1-C6 LPAPKNLVVSRVTEDSARLSWTAPDAAFDSFAIEYFEDWWSGEAIVLTVPGSERSCDLTG LKPGTEYSVTIRGVKGGYPSSPLSAIFTT
3D Structure
	Computationally Modelled Structure
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Template Name	Tencon

Protein Scaffold Information of This SBP
Scaffold ID	PS020 Scaffold Info					[1]
Scaffold Name	Centyrin
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Interleukin-17A	BTS Info	Inhibitor	Research tool	Kd: 1.8 nM	Janssen Research & Development, L.L.C.	[1]

References

1

Selection of high-affinity Centyrin FN3 domains from a simple library diversified at a combination of strand and loop positions. Protein Eng Des Sel. 2014 Oct;27(10):419-29.