Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS014)
PSS Name
Avimer
Synonyms
Maxibody; Avidity multimer
Diagrammatic Sketch
Highest Status Phase I
Class Non-Antibody
Fold Type (Ca2+) + Loops
Thermal Denaturation TEMP >37℃
Sequence Length 43 * n
Molecular Weight 4-18 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Low-density lipoprotein receptor A-domain Low-density lipoprotein receptor A-domain; Multimerized LDLR-A module; Ldl receptor domain A
1AJJ
Q5T700 ; A0A3Q1MCN2
Human; Synthetic construct
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Avimer AMG220 Phase I; Discontinued N.A. N.A. N.A.
SBP Info
 		[1], [2], [3]
Avimer anti-BAFF C2 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-CD28 C2810 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-CD40L C65 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-CII M13 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-CII M18 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-CII M26 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-HGFR C426 Research N.A. Escherichia coli Phage display
SBP Info
 		[3]
Avimer anti-FGFR1c C2987 Research N.A. N.A. Phage display
SBP Info
 		[4]
Avimer anti-FGFR1c/KLB C3201 Research N.A. N.A. Phage display
SBP Info
 		[4]
Avimer anti-FGFR1c/KLB C3209 Research N.A. N.A. Phage display
SBP Info
 		[4]
Avimer anti-KLB C2240 Research N.A. N.A. Phage display
SBP Info
 		[4]
References
1 In vitro-engineered non-antibody protein therapeutics. Protein Cell. 2018 Jan;9(1):3-14.
2 Recent advances in the development of novel protein scaffolds based therapeutics. Int J Biol Macromol. 2017 Sep;102:630-641.
3 Mult ivalent avimer proteins evolved by exon shuffling of a family of human receptor. Nat Biotechnol. 2005 Dec;23(12):1556-61.
4 FGF21 can be mimicked in vitro and in vivo by a novel anti-FGFR1c/-Klotho bispecific protein. PLoS One. 2013 Apr 22;8(4):e61432.