General Information of Synthetic Binding Protein (SBP) (ID: SBP000228)
SBP Name
Avimer anti-CD28 C2810
Synonyms
Avimer C2810
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS014
Scaffold Info
[1]
Scaffold Name Avimer
Scaffold Class Non-Antibody
Fold Type (Ca2+) + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
T-cell-specific surface glycoprotein CD28
BTS Info
Inhibitor Research tool Kd: 0.1 nM Avidia [1]
References
1 Mult ivalent avimer proteins evolved by exon shuffling of a family of human receptor. Nat Biotechnol. 2005 Dec;23(12):1556-61.