Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00019)
BTS Name
T-cell-specific surface glycoprotein CD28
Synonyms
TP44; CD antigen CD28
BTS Type
Protein
Gene Name
CD28
Organism
Homo sapiens (Human)
Function
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells
UniProt ID
P10747
UniProt Entry
CD28_HUMAN
PFam
PF15910
Gene ID
940
Sequence
MLRLLLALNLFPSIQVTGNKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLD
SAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPP
PYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKPFWVLVVVGGVLACYSLLVTVAFIIFWVR
SKRSRLLHSDYMNMTPRRPGPTRKHYQPYAPPRDFAAYRS
Sequence Length
220
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affibody anti-CD28 Z(CD28:5) Research Inhibitor Kd: 8500 nM Tools for inhibiting the CD28-CD80 co-stimulation signal
SBP Info
 		[1]
Avimer anti-CD28 C2810 Research Inhibitor Kd: 0.1 nM Research tool
SBP Info
 		[2]
References
1 Inhibition of the CD28-CD80 co-stimulation signal by a CD28-binding affibody ligand developed by combinatorial protein engineering. Protein Eng. 2003 Sep;16(9):691-7.
2 Mult ivalent avimer proteins evolved by exon shuffling of a family of human receptor. Nat Biotechnol. 2005 Dec;23(12):1556-61.