General Information of Synthetic Binding Protein (SBP) (ID: SBP000235)
SBP Name
Avimer anti-CII M18
Synonyms
Avimer M18
Molecular Weight 4.5 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 42
SBP Sequence
>Avimer anti-CII M18
CMANQFKCRSSRTCLLPGWVCDGIDDCPDGSDESPVTCPTPT
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS014
Scaffold Info
[1]
Scaffold Name Avimer
Scaffold Class Non-Antibody
Fold Type (Ca2+) + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Collagen alpha-1(II) chain
BTS Info
Binder Research tool Kd: 0.22 nM Avidia [1]
References
1 Mult ivalent avimer proteins evolved by exon shuffling of a family of human receptor. Nat Biotechnol. 2005 Dec;23(12):1556-61.