Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS005)
PSS Name
Affilin
Synonyms
Crystallin-based binder; Ubiquitin-based binder
Diagrammatic Sketch
Highest Status Research
Class Non-Antibody
Fold Type Beta-Sheets + Beta-Turns + Loops
Thermal Denaturation TEMP 56-72℃
Sequence Length 176-182
Molecular Weight 17-22 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Gamma-crystallin B Gamma-B-crystallin; Gamma-crystallin 1-2
2JDF
P07316 ; P02526
Human; Bovine
Ubiquitin N.A.
1UBQ
P0CG48
Human; Bovine
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Affilin anti-Estradiol/Testosterone SPC-4-10 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-Estradiol/Testosterone SPC-4-B6 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-FN 77405 Research Ubiquitin Escherichia coli NovaBlue (DE3) Phage display
SBP Info
 		[2]
Affilin anti-HPV16 D1C14 Research Gamma-B-crystallin Escherichia coli BL21 (DE3); Escherichia coli NovaBlue (DE3) Phage display
SBP Info
 		[3]
Affilin anti-HPV16 D4C14 Research Gamma-B-crystallin Escherichia coli BL21 (DE3); Escherichia coli NovaBlue (DE3) Phage display
SBP Info
 		[3]
Affilin anti-IgG-Fc SPC-1-A1 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-IgG-Fc SPC-1-A7 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-proNGF SPC-7-E9 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-proNGF SPC-7-F11 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-proNGF SPC-7-H1 Research Gamma-B-crystallin Escherichia coli Phage display
SBP Info
 		[1]
Affilin anti-Neuron SPVF 2801-10 Research Ubiquitin N.A. N.A.
SBP Info
 		[4]
Affilin anti-Neuron SPVF 2801-30 Research Ubiquitin N.A. N.A.
SBP Info
 		[4]
Affilin anti-Neuron SPVF 2801-40 Research Ubiquitin N.A. N.A.
SBP Info
 		[4]
Affilin anti-Cytokine receptor SPVF 2805-40 Research N.A. N.A. N.A.
SBP Info
 		[5]
Affilin anti-Serum protein SPWF-2802 Research N.A. N.A. N.A.
SBP Info
 		[5]
Affilin anti-Serum protein SPWF-2803 Research N.A. N.A. N.A.
SBP Info
 		[5]
References
1 Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein. J Mol Biol. 2007 Sep 7;372(1):172-85.
2 Novel ubiquitin-derived high affinity binding proteins with tumor targeting properties. J Biol Chem. 2014 Mar 21;289(12):8493-507.
3 Affilin molecules selected against the human papillomavirus E7 protein inhibit the proliferation of target cells. J Mol Biol. 2009 Jul 24;390(4):710-21.
4 ScilProteins(Navigo Proteins GmbH). Product Development Pipeline.
5 NavigoProteins. Product Development Pipeline. 2021.