Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS003)
PSS Name	Abl/Hck SH3 domain
Synonyms	Abl/Hck SH3 domain-based binder
Diagrammatic Sketch
Highest Status	Research
Class	Non-Antibody
Fold Type	Beta-Sheets + Loops
Thermal Denaturation TEMP	38-45℃
Sequence Length	57-60
Molecular Weight	6-7 kDa

Parental Protein of This PSS

Parental Protein Name	Synonym	PDB ID	UniProt ID	Origin
Abl-SH3 domain	N.A.	1BBZ	P00519	Human
Hck-SH3 domain	N.A.	3NHN	P08631	Human

Synthetic Binding Protein (SBP) Featuring this PSS

SBP Name	Highest Status	Template	Expression System	Selection Method	Details	Ref
Abl/Hck SH3 domain anti-ADAM15 clone 15.1	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-ADAM15/HIV-1 clone 15.2	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-ADAM15/HIV-1 clone 15.3	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-CD3E Epsilon1	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-CD3E Epsilon2	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-CD3E Epsilon3	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-HIV-1 Nef A1	Research	Hck-SH3	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[2]
Abl/Hck SH3 domain anti-HIV-1 Nef B4	Research	Hck-SH3	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[2]
Abl/Hck SH3 domain anti-HIV-1 Nef B6	Research	Hck-SH3	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[2]
Abl/Hck SH3 domain anti-HIV-1 Nef C1	Research	Hck-SH3	Escherichia coli BL21 (DE3)	Phage display	SBP Info	[2]
Abl/Hck SH3 domain anti-PAK-1 P1	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-PAK-1 P2	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-PAK-1/HIV-1 P3	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-PI3K p85-alpha clone 85.1	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-PI3K p85-alpha clone 85.2	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-PI3K p85-alpha clone 85.3	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-Sos1 S1	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-Sos1 S2	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]
Abl/Hck SH3 domain anti-Sos1 S3	Research	Hck-SH3	Escherichia coli	Phage display	SBP Info	[1]

References

1	Versatile retargeting of SH3 domain binding by modification of non-conserved loop residues. FEBS Lett. 2007 May 1;581(9):1735-41.
2	SH3 domains with high affinity and engineered ligand specificities targeted to HIV-1 Nef. J Mol Biol. 1999 Nov 12;293(5):1097-106.