Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP000811) | ||||||
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SBP Name |
Abl/Hck SH3 domain anti-HIV-1 Nef B6
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Synonyms |
Abl/Hck SH3 domain-based binder B6
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Molecular Weight | 6.5 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli BL21 (DE3) | |||||
Selection Method | Phage display | |||||
Highest Status | Research | |||||
Sequence Length | 57 | |||||
SBP Sequence |
>Abl/Hck SH3 domain anti-HIV-1 Nef B6
GPNSHNSNTPGIREAGSEDIIVVALYDYYSPFSWDLSFQKGDQMVVLEESGEWWKAR |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | Hck-SH3 | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS003 | [1] | ||||
Scaffold Name | Abl/Hck SH3 domain | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Protein Nef | Inhibitor | Human immunodeficiency virus infection (HIV infection) [ICD-11: 1C62.Z] | Kd: 7 nM | University of Tampere | [1] | |