Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000810) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Abl/Hck SH3 domain anti-HIV-1 Nef A1
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| Synonyms |
Abl/Hck SH3 domain-based binder A1
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| Molecular Weight | 6.4 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli BL21 (DE3) | |||||
| Selection Method | Phage display | |||||
| Highest Status | Research | |||||
| Sequence Length | 57 | |||||
| SBP Sequence |
>Abl/Hck SH3 domain anti-HIV-1 Nef A1
GPNSHNSNTPGIREAGSEDIIVVALYDYVSWSPDDLSFQKGDQMVVLEESGEWWKAR |
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| 3D Structure | ||||||
| Computationally Modelled Structure | ||||||
| Click to Save PDB File | ||||||
| Template Name | Hck-SH3 | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS003 | [1] | ||||
| Scaffold Name | Abl/Hck SH3 domain | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Protein Nef | Inhibitor | Human immunodeficiency virus infection (HIV infection) [ICD-11: 1C62.Z] | Kd: 7 nM | University of Tampere | [1] | |