Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00409)
BTS Name
Immunoglobulin E
Synonyms
IgE
BTS Type
Protein
Organism
Homo sapiens (Human)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affibody anti-IgE clone Z Research Binder Kd: 400 nM Research tool
SBP Info
 		[1]
DARPin anti-IgE E07 Research Inhibitor Kd: 3.4 nM Allergies [ICD-11: 4A84.Z]
SBP Info
 		[2]
DARPin anti-IgE E2_79 Research Binder N.A. Allergies [ICD-11: 4A84.Z]
SBP Info
 		[3]
DARPin anti-IgE E3_53 Research Inhibitor Kd: 21.48 nM Allergies [ICD-11: 4A84.Z]
SBP Info
 		[2]
DARPin anti-IgE E53 Research Binder Kd: 1.8 nM Allergies [ICD-11: 4A84.Z]
SBP Info
 		[4], [5]
References
1 Staphylococcal surface display of immunoglobulin A (IgA)- and IgE-specific in vitro-selected binding proteins (affibodies) based on Staphylococcus aureus protein A. Appl Environ Microbiol. 1999 Sep;65(9):4134-40.
2 Structure-guided design of ultrapotent disruptive IgE inhibitors to rapidly terminate acute allergic reactions. J Allergy Clin Immunol. 2021 Oct;148(4):1049-1060.
3 Sensing and responding to allergic response cytokines through a genetically encoded circuit. Nat Commun. 2017 Oct 24;8(1):1101.
4 Current Strategies to Inhibit High Affinity FcRI-Mediated Signaling for the Treatment of Allergic Disease. Front Immunol. 2019 Feb 7;10:175.
5 Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein. Allergy. 2011 Jul;66(7):961-8.