Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001469)
SBP Name
DARPin anti-IgE E53
Synonyms
DARPin E53
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Ribosome display
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS027
Scaffold Info
[1] , [2]
Scaffold Name DARPin
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Immunoglobulin E
BTS Info
Binder Allergies [ICD-11: 4A84.Z] Kd: 1.8 nM University of South Carolina [1] , [2]
References
1 Current Strategies to Inhibit High Affinity FcRI-Mediated Signaling for the Treatment of Allergic Disease. Front Immunol. 2019 Feb 7;10:175.
2 Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein. Allergy. 2011 Jul;66(7):961-8.