General Information of Binding Target of SBP (BTS) (ID: ST00367)
BTS Name
Immunoglobulin G
Synonyms
IgG
BTS Type
Protein
Organism
Homo sapiens (Human)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affitin anti-IgG C3 Research Binder Kd: 74 nM Tools for tolerating alternative library designs
SBP Info
[1]
Affitin anti-IgG D1 Research Binder Kd: 34 nM Tools for tolerating alternative library designs
SBP Info
[1]
Affitin anti-IgG D1Sac7d Research Binder Kd: 34 nM Tools for enhancing pH stability
SBP Info
[2]
Affitin anti-IgG D1Sso7d Research Binder Kd: 1500 nM Tools for enhancing pH stability
SBP Info
[2]
Affitin anti-IgG D1Sso7d (E36L) Research Binder Kd: 300 nM Tools for enhancing pH stability
SBP Info
[2]
Affitin anti-IgG D1Sso7d (K13L) Research Binder Kd: 300 nM Tools for enhancing pH stability
SBP Info
[2]
Affitin anti-IgG D1Sso7d DM Research Binder Kd: 4000 nM Tools for enhancing pH stability
SBP Info
[2]
Affitin anti-IgG L28K Research Binder Kd: 31 nM Tools for tolerating alternative library designs
SBP Info
[1]
Affitin anti-IgG N44A Research Binder Kd: 51 nM Tools for tolerating alternative library designs
SBP Info
[1]
Fab anti-IgG Ab2 Research Inhibitor N.A. Glanzmann thrombasthenia [ICD-11: 3B62.0Y]
SBP Info
[3]
Gp2-based binder anti-IgG GalphaGIgG(2.2.1) Research Binder Kd: 0.4 nM Research tool
SBP Info
[4]
Gp2-based binder anti-IgG GalphaRIgG(3.2.3) Research Binder Kd: 1 nM Research tool
SBP Info
[4]
Nanobody anti-HER2 MIRC213-709 Research Inhibitor Kd: 1271 nM Tools for prolonging nanobody-based radiotracer plasma half-life and enhancing the efficacy of tumor-targeted radionuclide therapy
SBP Info
[5]
References
1 Tolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G Affitins. Protein Eng Des Sel. 2013 Apr;26(4):267-75.
2 Switching an anti-IgG binding site between archaeal extremophilic proteins results in Affitins with enhanced pH stability. J Biotechnol. 2014 Dec 20;192 Pt A:123-9.
3 Repertoire cloning of a human IgG inhibitor of alpha IIB beta 3 function. The OG idiotype. Mol Immunol. 1995 Jun;32(9):613-22.
4 A 45-Amino-Acid Scaffold Mined from the PDB for High-Affinity Ligand Engineering. Chem Biol. 2015 Jul 23;22(7):946-56.
5 IgG-Binding Nanobody Capable of Prolonging Nanobody-Based Radiotracer Plasma Half-Life and Enhancing the Efficacy of Tumor-Targeted Radionuclide Therapy. Bioconjug Chem. 2022 Jul 20;33(7):1328-1339.