Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003602)
SBP Name	Nanobody anti-HER2 MIRC213-709
Synonyms	Nanobody MIRC213-709
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System	Escherichia coli BL21 (DE3)
Selection Method	Phage display
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS048 Scaffold Info					[1]
Scaffold Name	Nanobody
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Immunoglobulin G	BTS Info	Inhibitor	Tools for prolonging nanobody-based radiotracer plasma half-life and enhancing the efficacy of tumor-targeted radionuclide therapy	Kd: 1271 nM	Peking University	[1]
Epidermal growth factor receptor	BTS Info	Inhibitor	Tools for prolonging nanobody-based radiotracer plasma half-life and enhancing the efficacy of tumor-targeted radionuclide therapy	IC50: 29.47 nM	Peking University	[1]
Immunoglobulin G	BTS Info	Inhibitor	Tools for prolonging nanobody-based radiotracer plasma half-life and enhancing the efficacy of tumor-targeted radionuclide therapy	Kd: 434.4 nM	Peking University	[1]

References

1

IgG-Binding Nanobody Capable of Prolonging Nanobody-Based Radiotracer Plasma Half-Life and Enhancing the Efficacy of Tumor-Targeted Radionuclide Therapy. Bioconjug Chem. 2022 Jul 20;33(7):1328-1339.