Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00187)
BTS Name
Suppressor of tumorigenicity 14 protein
Synonyms
EC 3.4.21.109; Matriptase; Membrane-type serine protease 1; MT-SP1; Prostamin; Serine protease 14; Serine protease TADG-15; Tumor-associated differentially-expressed gene 15 protein
BTS Type
Protein
Family
Peptidase S1 family
Gene Name
ST14
Organism
Homo sapiens (Human)
Function
Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.
UniProt ID
Q9Y5Y6
UniProt Entry
ST14_HUMAN
PFam
PF00431 ; PF00057 ; PF01390 ; PF00089
Gene ID
6768
Sequence
MGSDRARKGGGGPKDFGAGLKYNSRHEKVNGLEEGVEFLPVNNVKKVEKHGPGRWVVLAA
VLIGLLLVLLGIGFLVWHLQYRDVRVQKVFNGYMRITNENFVDAYENSNSTEFVSLASKV
KDALKLLYSGVPFLGPYHKESAVTAFSEGSVIAYYWSEFSIPQHLVEEAERVMAEERVVM
LPPRARSLKSFVVTSVVAFPTDSKTVQRTQDNSCSFGLHARGVELMRFTTPGFPDSPYPA
HARCQWALRGDADSVLSLTFRSFDLASCDERGSDLVTVYNTLSPMEPHALVQLCGTYPPS
YNLTFHSSQNVLLITLITNTERRHPGFEATFFQLPRMSSCGGRLRKAQGTFNSPYYPGHY
PPNIDCTWNIEVPNNQHVKVRFKFFYLLEPGVPAGTCPKDYVEINGEKYCGERSQFVVTS
NSNKITVRFHSDQSYTDTGFLAEYLSYDSSDPCPGQFTCRTGRCIRKELRCDGWADCTDH
SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK
SQQCNGKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEK
DCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYID
DRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKP
AEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLL
PQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYT
RLPLFRDWIKENTGV
Sequence Length
855
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Knottin anti-FXIIa cMCoFx1 Research Inhibitor Ki: 9120 nM Tools for inhibiting Human beta-Factor XIIa
SBP Info
 		[1]
Knottin anti-FXIIa cMCoTI-fxL1 Research Inhibitor Ki: 2210 nM Tools for inhibiting Human beta-Factor XIIa
SBP Info
 		[1]
Knottin anti-FXIIa cMCoTI-fxL5 Research Inhibitor Ki: 17 nM Tools for inhibiting Human beta-Factor XIIa
SBP Info
 		[1]
Knottin anti-Matriptase-1 MCoTI Var. 1 Research Inhibitor Ki: 4.4 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Knottin anti-Matriptase-1 MCoTI Var. 2 Research Inhibitor Ki: 3.3 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Knottin anti-Matriptase-1 MCoTI Var. 3 Research Inhibitor Ki: 7.8 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Knottin anti-Matriptase-1 MCoTI Var. 4 Research Inhibitor Ki: 0.83 nM Cancers [ICD-11: 2D4Z]; Arthritic therapy
SBP Info
 		[2]
Knottin anti-Matriptase-1 SOTI Var. 1 Research Inhibitor Ki: 28.9 nM Cancers [ICD-11: 2D4Z]; Arthritic
SBP Info
 		[2]
Knottin MCoLib Research Activator Kd: 0.4 nM Tools for regulating activity research
SBP Info
 		[3]
References
1 An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human -Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489.
2 Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1. PLoS One. 2013 Oct 11;8(10):e76956.
3 Cystine Knot Peptides with Tuneable Activity and Mechanism. Angew Chem Int Ed Engl. 2022 May 2;61(19):e202200951.