Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003524) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Knottin anti-FXIIa cMCoFx1
|
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| Synonyms |
Knottin cMCoFx1
|
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| Molecular Weight | 3.6 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | mRNA display | |||||
| Highest Status | Research | |||||
| PDB ID | 7FBP | |||||
| Sequence Length | 34 | |||||
| SBP Sequence |
>Knottin anti-FXIIa cMCoFx1
DGGICPRIGRLCRRDSDCPGACICRATRFCGSGY |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS042 | [1] | ||||
| Scaffold Name | Knottin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Serine protease 1 | Inhibitor | Tools for inhibiting Human beta-Factor XIIa | Ki: 1110 nM | University of Tokyo | [1] | |
| Coagulation factor XII | Inhibitor | Tools for inhibiting Human beta-Factor XIIa | Ki: 0.37 nM | University of Tokyo | [1] | |
| Suppressor of tumorigenicity 14 protein | Inhibitor | Tools for inhibiting Human beta-Factor XIIa | Ki: 9120 nM | University of Tokyo | [1] | |