Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00577) | ||||||
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| BTS Name |
Coagulation factor XII
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| Synonyms |
Hageman factor; HAF; EC:3.4.21.38
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| BTS Type |
Protein
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| Family |
peptidase S1 family
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| Gene Name |
F12
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| Organism |
Homo sapiens (Human)
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| Function |
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then trypsin cleaves it to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MRALLLLGFLLVSLESTLSIPPWEAPKEHKYKAEEHTVVLTVTGEPCHFPFQYHRQLYHK
CTHKGRPGPQPWCATTPNFDQDQRWGYCLEPKKVKDHCSKHSPCQKGGTCVNMPSGPHCL CPQHLTGNHCQKEKCFEPQLLRFFHKNEIWYRTEQAAVARCQCKGPDAHCQRLASQACRT NPCLHGGRCLEVEGHRLCHCPVGYTGAFCDVDTKASCYDGRGLSYRGLARTTLSGAPCQP WASEATYRNVTAEQARNWGLGGHAFCRNPDNDIRPWCFVLNRDRLSWEYCDLAQCQTPTQ AAPPTPVSPRLHVPLMPAQPAPPKPQPTTRTPPQSQTPGALPAKREQPPSLTRNGPLSCG QRLRKSLSSMTRVVGGLVALRGAHPYIAALYWGHSFCAGSLIAPCWVLTAAHCLQDRPAP EDLTVVLGQERRNHSCEPCQTLAVRSYRLHEAFSPVSYQHDLALLRLQEDADGSCALLSP YVQPVCLPSGAARPSETTLCQVAGWGHQFEGAEEYASFLQEAQVPFLSLERCSAPDVHGS SILPGMLCAGFLEGGTDACQGDSGGPLVCEDQAAERRLTLQGIISWGSGCGDRNKPGVYT DVAYYLAWIREHTVS |
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| Sequence Length |
615
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
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| Knottin anti-FXIIa cMCoFx1 | Research | Inhibitor | Ki: 0.37 nM | Tools for inhibiting Human beta-Factor XIIa | [1] | |
| Knottin anti-FXIIa cMCoTI-fxL1 | Research | Inhibitor | Ki: 0.69 nM | Tools for inhibiting Human beta-Factor XIIa | [1] | |
| Knottin anti-FXIIa cMCoTI-fxL5 | Research | Inhibitor | Ki: 66 nM | Tools for inhibiting Human beta-Factor XIIa | [1] | |
| Knottin MCoLib | Research | Activator | Kd: 3.3 nM | Tools for regulating activity research | [2] | |