Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003525)
SBP Name	Knottin anti-FXIIa cMCoTI-fxL1
Synonyms	Knottin cMCoTI-fxL1
Molecular Weight	3.5 kDa
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method	mRNA display
Highest Status	Research
Sequence Length	34
SBP Sequence	>Knottin anti-FXIIa cMCoTI-fxL1 DGGICPRIGRLCRRDSDCPGACICRGNGYCGSGS
3D Structure
	Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID	PS042 Scaffold Info					[1]
Scaffold Name	Knottin
Scaffold Class	Non-Antibody
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Serine protease 1	BTS Info	Inhibitor	Tools for inhibiting Human beta-Factor XIIa	Ki: 996 nM	University of Tokyo	[1]
Coagulation factor XII	BTS Info	Inhibitor	Tools for inhibiting Human beta-Factor XIIa	Ki: 0.69 nM	University of Tokyo	[1]
Suppressor of tumorigenicity 14 protein	BTS Info	Inhibitor	Tools for inhibiting Human beta-Factor XIIa	Ki: 2210 nM	University of Tokyo	[1]

References

1

An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human -Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489.