General Information of Synthetic Binding Protein (SBP) (ID: SBP003526)
SBP Name
Knottin anti-FXIIa cMCoTI-fxL5
Synonyms
Knottin cMCoTI-fxL5
Molecular Weight 3.6 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method mRNA display
Highest Status Research
Sequence Length 34
SBP Sequence
>Knottin anti-FXIIa cMCoTI-fxL5
DGGVCPKILKKCRRDSDCPGACICRATRFCGSGS
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS042
Scaffold Info
[1]
Scaffold Name Knottin
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Serine protease 1
BTS Info
Inhibitor Tools for inhibiting Human beta-Factor XIIa Ki: 0.08 nM University of Tokyo [1]
Coagulation factor XII
BTS Info
Inhibitor Tools for inhibiting Human beta-Factor XIIa Ki: 66 nM University of Tokyo [1]
Suppressor of tumorigenicity 14 protein
BTS Info
Inhibitor Tools for inhibiting Human beta-Factor XIIa Ki: 17 nM University of Tokyo [1]
References
1 An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human -Factor XIIa in a Cyclotide Scaffold. J Am Chem Soc. 2021 Nov 10;143(44):18481-18489.