Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000520)
SBP Name
Knottin anti-Matriptase-1 SOTI Var. 1
Synonyms
Knottin SOTI Var. 1
Molecular Weight 4.0 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
Sequence Length 37
SBP Sequence
>Knottin anti-Matriptase-1 SOTI Var. 1
EDKCSPSGAICSGFGPPEQCCSGACVLNRRARSWRCQ
Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
3D Structure
Computationally Modelled Structure
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Template Name SOTI-
Template Sequence Description Cys I and Cys IV form disulfide bonds; Cys II and Cys V form disulfide bonds; Cys III and Cys VI form disulfide bonds.
Protein Scaffold Information of This SBP
Scaffold ID PS042
Scaffold Info
[1]
Scaffold Name Knottin
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Suppressor of tumorigenicity 14 protein
BTS Info
Inhibitor Cancers [ICD-11: 2D4Z]; Arthritic Ki: 28.9 nM Technical University of Darmstadt [1]
References
1 Combinatorial optimization of cystine-knot peptides towards high-affinity inhibitors of human matriptase-1. PLoS One. 2013 Oct 11;8(10):e76956.