General Information of Binding Target of SBP (BTS) (ID: ST00051)
BTS Name
Albumin
Synonyms
BSA; allergen Bos d 6
BTS Type
Protein
Family
ALB/AFP/VDB family
Gene Name
ALB
Organism
Bos taurus (Bovine)
Function
Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc (By similarity). Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma (Probable). Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner The shared binding site between zinc and calcium at residue Asp-272 suggests a crosstalk between zinc and calcium transport in the blood (Probable). The rank order of affinity is zinc > calcium > magnesium (Probable). Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli Does not prevent iron uptake by the bacterial siderophore aerobactin
UniProt ID
P02769
UniProt Entry
ALBU_BOVIN
PFam
PF00273
Gene ID
280717
Sequence
MKWVTFISLLLLFSSAYSRGVFRRDTHKSEIAHRFKDLGEEHFKGLVLIAFSQYLQQCPF
DEHVKLVNELTEFAKTCVADESHAGCEKSLHTLFGDELCKVASLRETYGDMADCCEKQEP
ERNECFLSHKDDSPDLPKLKPDPNTLCDEFKADEKKFWGKYLYEIARRHPYFYAPELLYY
ANKYNGVFQECCQAEDKGACLLPKIETMREKVLASSARQRLRCASIQKFGERALKAWSVA
RLSQKFPKAEFVEVTKLVTDLTKVHKECCHGDLLECADDRADLAKYICDNQDTISSKLKE
CCDKPLLEKSHCIAEVEKDAIPENLPPLTADFAEDKDVCKNYQEAKDAFLGSFLYEYSRR
HPEYAVSVLLRLAKEYEATLEECCAKDDPHACYSTVFDKLKHLVDEPQNLIKQNCDQFEK
LGEYGFQNALIVRYTRKVPQVSTPTLVEVSRSLGKVGTRCCTKPESERMPCTEDYLSLIL
NRLCVLHEKTPVSEKVTKCCTESLVNRRPCFSALTPDETYVPKAFDEKLFTFHADICTLP
DTEKQIKKQTALVELLKHKPKATEEQLKTVMENFVAFVDKCCAADDKEACFAVEGPKLVV
STQTALA
Sequence Length
607
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Affitin anti-BSA Sso7d\2A8 Research Binder Kd: 3500 nM Diagnostics and therapeutics for environments with extreme conditions of storage and deployment
SBP Info
[1]
Cytochrome b562-based binder anti-BSA-1 conjugate C13 Research Binder Kd: 5000 nM Tools for molecular recognition
SBP Info
[2]
Cytochrome b562-based binder anti-BSA-1 conjugate C18 Research Binder Kd: 8600 nM Tools for molecular recognition
SBP Info
[2]
Cytochrome b562-based binder anti-BSA-1 conjugate C22 Research Binder Kd: 9400 nM Tools for molecular recognition
SBP Info
[2]
Cytochrome b562-based binder anti-BSA-1 conjugate C30 Research Binder Kd: 22000 nM Tools for molecular recognition
SBP Info
[2]
Fab anti-Progesterone-BSA A11 Research Binder N.A. Research tool
SBP Info
[3]
Fab anti-Progesterone-BSA B6 Research Binder N.A. Research tool
SBP Info
[3]
Fab anti-Progesterone-BSA F1 Research Binder N.A. Research tool
SBP Info
[3]
scFv anti-BSA-O-polysaccharide B3-19 Research Binder N.A. Research tool
SBP Info
[4]
scFv anti-BSA-O-polysaccharide B3-20 Research Binder N.A. Research tool
SBP Info
[4]
scFv anti-BSA-O-polysaccharide B5-1/B1-4 Research Binder N.A. Research tool
SBP Info
[4]
scFv anti-BSA-O-polysaccharide B5-6 Research Binder N.A. Research tool
SBP Info
[4]
scFv anti-BSA-O-polysaccharide Glyl09Ser Research Binder N.A. Tools as a tendency to dimerize
SBP Info
[4]
References
1 Phage display selection of tight specific binding variants from a hyperthermostable Sso7d scaffold protein library.FEBS J. 2016 Apr;283(7):1351-67.
2 Alternate protein frameworks for molecular recognition. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6552-6.
3 In vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin library. Proc Natl Acad Sci U S A. 1992 Apr 15;89(8):3576-80.
4 Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene libraries. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4992-6.