General Information of Protein Scaffold of SBP (PSS) (ID: PS008)
PSS Name
Alphabody
Diagrammatic Sketch
Highest Status Research
Class Non-Antibody
Fold Type Alpha-Helices + Loops
Thermal Denaturation TEMP 80-120℃
Sequence Length 70-118
Molecular Weight 10-12 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Peptide N.A. N.A. N.A. Synthetic construct
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Alphabody anti-IL-23 Cl59 Research N.A. Escherichia coli Phage display
SBP Info
[1]
Alphabody anti-IL-23 MA12 Research N.A. Escherichia coli Phage display
SBP Info
[1]
Alphabody anti-IL-23 MA5 Research N.A. Escherichia coli Phage display
SBP Info
[1]
Alphabody anti-MCL-1 Research N.A. N.A. N.A.
SBP Info
[2]
Alphabody anti-SARS-CoV-2 Research N.A. N.A. N.A.
SBP Info
[3]
Alphabody anti-TNF-alpha/IL-23 CMX-02 Research N.A. N.A. N.A.
SBP Info
[3]
References
1 Structural basis of IL-23 antagonism by an Alphabody protein scaffold. Nat Commun. 2014 Oct 30;5:5237.
2 First-in-class cell penetrating proteins targeting Mcl-1 induce tumor cell apoptosis and inhibition of tumor growth in vivo. European Journal of Cancer. 69(S132-S133). December 2016.
3 Complix. Product Development Pipeline. 2021.