General Information of Synthetic Binding Protein (SBP) (ID: SBP000595)
SBP Name
Alphabody anti-MCL-1
Synonyms
Anti-MCL-1 Alphabody
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Protein Scaffold Information of This SBP
Scaffold ID PS008
Scaffold Info
[1]
Scaffold Name Alphabody
Scaffold Class Non-Antibody
Fold Type Alpha-Helices + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Induced myeloid leukemia cell differentiation protein Mcl-1
BTS Info
Binder Tools for chemotherapeutic resistance and disease relapse N.A. Complix [1]
References
1 First-in-class cell penetrating proteins targeting Mcl-1 induce tumor cell apoptosis and inhibition of tumor growth in vivo. European Journal of Cancer. 69(S132-S133). December 2016.