Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP000239) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
DARPin anti-Bcl-2/BCL-XL/Bcl-W 008_C6
|
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| Synonyms |
DARPin 008_C6
|
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| Molecular Weight | 19.7 kDa | |||||
| Thermal Denaturation TEMP | 65 ℃ | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Expression System | Escherichia coli | |||||
| Selection Method | Ribosome display | |||||
| Highest Status | Research | |||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS027 | [1] | ||||
| Scaffold Name | DARPin | |||||
| Scaffold Class | Non-Antibody | |||||
| Fold Type | Alpha-Helices + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
|---|
| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Bcl-2-like protein 2 | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 2.9 nM | University of Zurich | [1] | |
| Apoptosis regulator Bcl-X | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 1.0 nM | University of Zurich | [1] | |
| Apoptosis regulator Bcl-2 | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 0.03 nM | University of Zurich | [1] | |