Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00115) | ||||||
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| BTS Name |
Bcl-2-like protein 2
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| Synonyms |
Bcl2-L-2; Apoptosis regulator Bcl-W; c98
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| BTS Type |
Protein
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| Family |
Bcl-2 family
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| Gene Name |
Bcl2l2
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| Organism |
Mus musculus (Mouse)
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| Function |
Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MATPASTPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRT
FSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVG QVQDWMVAYLETRLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVAL GALVTVGAFFASK |
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| Sequence Length |
193
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| DARPin anti-Bcl-2/BCL-XL/Bcl-W 008_C6 | Research | Inhibitor | Kd: 2.9 nM | Cancers [ICD-11: 2D4Z] | [1] | |