Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00441)
BTS Name
Fluc channel homologue Bpe
Synonyms
Bpe
BTS Type
Protein
Organism
Bacteria
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-Bpe clone L3 Research Inhibitor Kd: 58 nM Tools for inhibiting dual topology fluoride channels
SBP Info
 		[1], [2], [3]
Monobody anti-Bpe L2 Research Binder N.A. Tools as monobody inhibitor
SBP Info
 		[4], [2], [1]
Monobody anti-Bpe S7 Research Binder N.A. Research tool
SBP Info
 		[4], [1]
Monobody anti-Bpe S8 Research Blocker Kd: 200000 nM Research tool
SBP Info
 		[5]
References
1 Proof of dual-topology architecture of Fluc F- channels with monobody blockers. Nat Commun. 2014 Oct 7;5:5120.
2 Mechanism of single- and double-sided inhibition of dual topology fluoride channels by synthetic monobodies. J Gen Physiol. 2017 Apr 3;149(4):511-522.
3 Two-sided block of a dual-topology F- channel. Proc Natl Acad Sci U S A. 2015 May 5;112(18):5697-701.
4 Crystal structures of a double-barrelled fluoride ion channel. Nature. 2015 Sep 24;525(7570):548-51.
5 Cork-in-Bottle Occlusion of Fluoride Ion Channels by Crystallization Chaperones. Structure. 2018 Apr 3;26(4):635-639.e1.