Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00320) | ||||||
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| BTS Name |
Beta-2 adrenergic receptor
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| Synonyms |
Beta-2 adrenoreceptor; Beta-2 adrenoceptor
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| BTS Type |
Protein
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| Family |
G-protein coupled receptor 1 family;
Adrenergic receptor subfamily; ADRB2 sub-subfamily |
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| Gene Name |
ADRB2
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| Organism |
Homo sapiens (Human)
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| Function |
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL |
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| Sequence Length |
413
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Nanobody anti-ADRB2 clone c200 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c201 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c202 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c203 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c204 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c205 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c206 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c207 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c208 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c209 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c210 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c211 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-ADRB2 clone c212 | Research | Modulator | Kd: 44-151 nM | Research tool | [1] | |
| Nanobody anti-beta2AR clone 6B9 | Research | Binder | EC50: 21 nM | Research tool | [2] | |