General Information of Synthetic Binding Protein (SBP) (ID: SBP003247)
SBP Name
Nanobody anti-ADRB2 clone c203
Synonyms
Nb.c203
Molecular Weight 13.8 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Yeast display
Highest Status Research
Sequence Length 124
SBP Sequence
>Nanobody anti-ADRB2 clone c203
QVQLQESGGGLVQAGGSLRLSCAASGYISDAYYMGWYRQAPGKEREFVATITHGTNTYYA
DSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAYSHTYTIFPWTLFYWGQGTQVTV
SSLE
3D Structure
Computationally Modelled Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS048
Scaffold Info
[1]
Scaffold Name Nanobody
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Beta-2 adrenergic receptor
BTS Info
Modulator Research tool Kd: 44-151 nM Harvard Medical School [1]
References
1 Yeast surface display platform for rapid discovery of conformationally selective nanobodies. Nat Struct Mol Biol. 2018 Mar;25(3):289-296.