Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00197)
BTS Name
GTPase HRas
Synonyms
EC 3.6.5.2; H-Ras-1; Ha-Ras; Transforming protein p21; c-H-ras; p21ras
BTS Type
Protein
Family
Small GTPase superfamily;
Ras family
Gene Name
HRAS
Organism
Homo sapiens (Human)
Function
Involved in the activation of Ras protein signal transduction Ras proteins bind GDP/GTP and possess intrinsic GTPase activity
UniProt ID
P01112
UniProt Entry
RASH_HUMAN
PFam
PF00071
Gene ID
3265
Sequence
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL
AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLVREIRQHKLRKLNPPDESGPG
CMSCKCVLS
Sequence Length
189
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-HRAS/NRAS/KRAS JAM20 Research Inhibitor Kd: 8 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Monobody anti-HRAS/NRAS/KRAS JAM20 Research Inhibitor Kd: 16 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Monobody anti-HRAS/NRAS/KRAS R15 Research Inhibitor Kd: 253 nM Tools for inhibition of selected oncogenic RAS mutants
SBP Info
 		[2]
Monobody anti-KRas/HRas NS1 Research Inhibitor Kd: 15 nM Pancreas cancer [ICD-11: 2C10.Z]
SBP Info
 		[3], [4]
Peptide aptamer anti-Ras Pep141 Research Inhibitor IC50: 100 nM Tools for protein function modulation
SBP Info
 		[5], [6]
Peptide aptamer anti-Ras Pep2 Research Binder N.A. Tools for protein function modulation
SBP Info
 		[5], [6]
Peptide aptamer anti-Ras Pep22 Research Inhibitor IC50: 500 nM Tools for protein function modulation
SBP Info
 		[5], [6]
References
1 Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2204481119.
2 Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants. Cell Rep. 2022 Feb 8;38(6):110322.
3 Targeting the KRAS 4-5 allosteric interface inhibits pancreatic cancer tumorigenesis. Small GTPases. 2021 May 5;1-14.
4 Targeting the 4-5 interface of RAS results in multiple levels of inhibition
5 Inactivation of Ras function by allele-specific peptide aptamers. Oncogene. 2002 Aug 22;21(37):5753-7.
6 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.