Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00090)
BTS Name
Carcinoembryonic antigen
Synonyms
Fragment
BTS Type
Protein
Gene Name
CEA
Organism
Homo sapiens (Human)
UniProt ID
Q13985
UniProt Entry
Q13985_HUMAN
PFam
PF07686
Sequence
MGPPSAPPCRLHVPWKEVLLTASLLTFWNPPTTAKLTIESTPFNVAEGKEVLLLAHNLPQ
NRIGYSWYKGERVDGNSLIVGYVIGTQQATPGPAYSGRETIYPNASLLIQNVTQNDTGFY
TLQVIKSDLVNEEATGQFHVY
Sequence Length
141
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
BiTE AMG-211 Phase I; Discontinued Stimulator N.A. GI adenocarcinoma [ICD-11: 2D40]
SBP Info
 		[1], [2]
Diabody anti-CEA T84.66 Research Binder N.A. Tools for rapid tumor targeting
SBP Info
 		[3], [4]
Diabody anti-CEA x anti-CD3 Research Binder N.A. Cancers [ICD-11: 2D4Z]
SBP Info
 		[5]
scFv anti-CEA HBA11 Research Binder Kd: 2.8 nM Immunotherapy
SBP Info
 		[6]
scFv anti-CEA HBB11 Research Binder Kd: 2 nM Immunotherapy
SBP Info
 		[6]
scFv anti-CEA HBB6 Research Binder Kd: 7.1 nM Immunotherapy
SBP Info
 		[6]
scFv anti-CEA LOE17 Research Binder Kd: 1 nM Immunotherapy
SBP Info
 		[6]
scFv anti-CEA LOSC2 Research Binder Kd: 9 nM Immunotherapy
SBP Info
 		[6]
scFv anti-CEA T06D10 Research Binder Kd: 1.4 nM Immunotherapy
SBP Info
 		[6]
References
1 Single-Chain Variable Fragment-Based Bispecific Antibodies: Hitting Two Targets with One Sophisticated Arrow. Mol Ther Oncolytics. 2019 Mar 23;14:38-56.
2 Molecular Imaging of Radiolabeled Bispecific T-Cell Engager 89 Zr-AMG211 Targeting CEA-Positive Tumors. Clin Cancer Res. 2018 Oct 15;24(20):4988-4996.
3 Mammalian expression and hollow fiber bioreactor production of recombinant anti-CEA diabody and minibody for clinical applications. J Immunol Methods. 2001 Jul 1;253(1-2):195-208.
4 The crystal structure of an anti-CEA scFv diabody assembled from T84.66 scFvs in V(L)-to-V(H) orientation: implications for diabody flexibility. J Mol Biol. 2003 Feb 14;326(2):341-51.
5 Balanced secretion of anti-CEA G anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity. Gene Ther. 2017 Apr;24(4):208-214.
6 Generation of a panel of related human scFv antibodies with high affinities for human CEA. Immunotechnology. 1996 Sep;2(3):181-96.