Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP001010)
SBP Name	Diabody anti-CEA x anti-CD3
Synonyms	Anti-CEA x anti-CD3 diabody
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS031 Scaffold Info					[1]
Scaffold Name	Diabody
Scaffold Class	Antibody fragment
Fold Type	Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
T-cell surface glycoprotein CD3	BTS Info	Binder	Cancers [ICD-11: 2D4Z]	N.A.	Aarhus University	[1]
Carcinoembryonic antigen	BTS Info	Binder	Cancers [ICD-11: 2D4Z]	N.A.	Aarhus University	[1]

References

1

Balanced secretion of anti-CEA G anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity. Gene Ther. 2017 Apr;24(4):208-214.