General Information of Synthetic Binding Protein (SBP) (ID: SBP001827)
SBP Name
scFv anti-CEA HBA11
Synonyms
scFv HBA11
Molecular Weight 26.0 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Expression System Escherichia coli
Selection Method Phage display
Highest Status Research
Sequence Length 246
SBP Sequence
>scFv anti-CEA HBA11
QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNSPINWLRQAPGQGLEWMGSIIPSFGTANY
AQKFQGRLTITADESTSTAYMELSSLRSEDTAVYYCAGANSCNRSYYYYMDVWGQGTMVT
VSSGGGGSGGGGSGGGGSDIQMTQSPSTLSASIGDRVTITCRASEGIYHWLAWYQQKPGK
APKLLIYKASSLASGAPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQYSNYPLTFGGGT
KLEIKR
3D Structure
Computationally Modelled Structure
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Template Name scFv CEA6
Protein Scaffold Information of This SBP
Scaffold ID PS057
Scaffold Info
[1]
Scaffold Name scFv
Scaffold Class Antibody fragment
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Carcinoembryonic antigen
BTS Info
Binder Immunotherapy Kd: 2.8 nM Cambridge Antibody Technology [1]
References
1 Generation of a panel of related human scFv antibodies with high affinities for human CEA. Immunotechnology. 1996 Sep;2(3):181-96.