Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP001829) | ||||||
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SBP Name |
scFv anti-CEA LOE17
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Synonyms |
scFv LOE17
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Molecular Weight | 26.1 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | Escherichia coli | |||||
Selection Method | Phage display | |||||
Highest Status | Research | |||||
Sequence Length | 246 | |||||
SBP Sequence |
>scFv anti-CEA LOE17
QVQLVQSGAEVKKPGSSVKVSCKASGGTFSNSPINWLRQAPGQGLEWMGSIIPSFGTANY AQKFQGRLTITADESTSTAYMELSSLRSEDTAVYYCAGRSHNYELYYYYMDVWGQGTMVT VSSGGGGSGGGGSGGGGSDIQMTQSPSTLSASIGDRVTITCRASEGIYHWLAWYQQKPGK APKLLIYKASSLASGAPSRFSGSGSGTDFTLTISSLQPDDFATYYCQQYDNGPLTFGGGT KLEIKR |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | scFv CEA6 | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS057 | [1] | ||||
Scaffold Name | scFv | |||||
Scaffold Class | Antibody fragment | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Carcinoembryonic antigen | Binder | Immunotherapy | Kd: 1 nM | Cambridge Antibody Technology | [1] | |