Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00001)
BTS Name
Receptor tyrosine-protein kinase erbB-3
Synonyms
EC 2.7.10.1; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3
BTS Type
Protein
Family
Protein kinase superfamily;
Tyr protein kinase family;
EGF receptor subfamily
Gene Name
ERBB3
Organism
Homo sapiens (Human)
Function
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase May also be activated by CSPG5 Involved in the regulation of myeloid cell differentiation
UniProt ID
P21860
UniProt Entry
ERBB3_HUMAN
PFam
PF00757 ; PF14843 ; PF07714 ; PF01030
Gene ID
2065
Sequence
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTEILSGGVYIEKNDKLCHMDTIDWRDIVRDRDAEIVVKDNG
RSCPPCHEVCKGRCWGPGSEDCQTLTKTICAPQCNGHCFGPNPNQCCHDECAGGCSGPQD
TDCFACRHFNDSGACVPRCPQPLVYNKLTFQLEPNPHTKYQYGGVCVASCPHNFVVDQTS
CVRACPPDKMEVDKNGLKMCEPCGGLCPKACEGTGSGSRFQTVDSSNIDGFVNCTKILGN
LDFLITGLNGDPWHKIPALDPEKLNVFRTVREITGYLNIQSWPPHMHNFSVFSNLTTIGG
RSLYNRGFSLLIMKNLNVTSLGFRSLKEISAGRIYISANRQLCYHHSLNWTKVLRGPTEE
RLDIKHNRPRRDCVAEGKVCDPLCSSGGCWGPGPGQCLSCRNYSRGGVCVTHCNFLNGEP
REFAHEAECFSCHPECQPMEGTATCNGSGSDTCAQCAHFRDGPHCVSSCPHGVLGAKGPI
YKYPDVQNECRPCHENCTQGCKGPELQDCLGQTLVLIGKTHLTMALTVIAGLVVIFMMLG
GTFLYWRGRRIQNKRAMRRYLERGESIEPLDPSEKANKVLARIFKETELRKLKVLGSGVF
GTVHKGVWIPEGESIKIPVCIKVIEDKSGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPG
SSLQLVTQYLPLGSLLDHVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNV
LLKSPSQVQVADFGVADLLPPDDKQLLYSEAKTPIKWMALESIHFGKYTHQSDVWSYGVT
VWELMTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENIRPTFKE
LANEFTRMARDPPRYLVIKRESGPGIAPGPEPHGLTNKKLEEVELEPELDLDLDLEAEED
NLATTTLGSALSLPVGTLNRPRGSQSLLSPSSGYMPMNQGNLGESCQESAVSGSSERCPR
PVSLHPMPRGCLASESSEGHVTGSEAELQEKVSMCRSRSRSRSPRPRGDSAYHSQRHSLL
TPVTPLSPPGLEEEDVNGYVMPDTHLKGTPSSREGTLSSVGLSSVLGTEEEDEDEEYEYM
NRRRRHSPPHPPRPSSLEELGYEYMDVGSDLSASLGSTQSCPLHPVPIMPTAGTTPDEDY
EYMNRQRDGGGPGGDYAAMGACPASEQGYEEMRAFQGPGHQAPHVHYARLKTLRSLEATD
SAFDNPDYWHSRLFPKANAQRT
Sequence Length
1342
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
ABD-derived affinity protein anti-ERBB3/HSA clone 1 Research Binder Kd: 75 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 13 Research Binder Kd: 39 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 18 Research Binder Kd: 94 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 2 Research Binder Kd: 26 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 20 Research Binder Kd: 60 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 27 Research Binder Kd: 12 nM Research tool
SBP Info
 		[1]
ABD-derived affinity protein anti-ERBB3/HSA clone 3 Research Binder Kd: 10 nM Research tool
SBP Info
 		[1]
Affibody anti-ERBB3 Z(05405) Research Binder Kd: 2.5 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Affibody anti-ERBB3 Z(05413) Research Binder Kd: 1.8 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Affibody anti-ERBB3 Z(05416) Research Binder Kd: 2.9 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Affibody anti-ERBB3 Z(05417) Research Binder Kd: 3 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[2]
Affibody anti-ERBB3 Z(08698) Research Inhibitor Kd: 0.05 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[3]
Affibody anti-ERBB3 Z(08699) Research Inhibitor Kd: 0.021 nM Tumors [ICD-11: XH1N44]
SBP Info
 		[3]
Bicyclic peptide anti-ERBB3 H33 Research Inhibitor Kd: 304 nM Cancers [ICD-11: 2D4Z]
SBP Info
Fynomer anti-ERBB3 C12 Research Binder Kd: 80 nM Cancers [ICD-11: 2D4Z]
SBP Info
 		[4]
References
1 Development and characterization of small bispecific albumin-binding domains with high affinity for ErbB3. Cell Mol Life Sci. 2013 Oct;70(20):3973-85.
2 Combining phage and staphylococcal surface display for generation of ErbB3-specific Affibody molecules. Protein Eng Des Sel. 2011 Apr;24(4):385-96.
3 Inhibiting HER3-mediated tumor cell growth with affibody molecules engineered to low picomolar affinity by position-directed error-prone PCR-like diversification. PLoS One. 2013 May 10;8(5):e62791.
4 A bispecific HER2-targeting FynomAb with superior antitumor activity and novel mode of action. Mol Cancer Ther. 2014 Aug;13(8):2030-9.