Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS033)
PSS Name
Evibody
Synonyms
CTLA4-based binder
Diagrammatic Sketch
Highest Status Research
Class Non-Antibody
Fold Type Beta-Sheets + Loops
Thermal Denaturation TEMP 90℃
Sequence Length 120-136
Molecular Weight 12-16 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Cytotoxic T-lymphocyte-associated antigen 4 CTLA-4
3BX7
P16410
Human
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
Evibody anti-HEWL clys12 Research CTLA-4 Escherichia coli Ribosome display
SBP Info
 		[1]
Evibody anti-Integrin RGD-7B Research CTLA-4 Escherichia coli Phage display
SBP Info
 		[2]
Evibody anti-Somatostatin receptor CTLA-4R(cys121)Som1 Research CTLA-4R Escherichia coli Phage display
SBP Info
 		[3], [4]
Evibody anti-Somatostatin receptor CTLA-4R-Som1 Research CTLA-4R Escherichia coli Phage display
SBP Info
 		[3], [4]
Evibody anti-Somatostatin receptor CTLA-4R-Som3 Research CTLA-4R Escherichia coli Phage display
SBP Info
 		[3], [4]
References
1 Ribosome display and affinity maturation: from antibodies to single V-domains and steps towards cancer therapeutics. J Immunol Methods. 2001 Feb 1;248(1-2):31-45.
2 Development and application of cytotoxic T lymphocyte-associated antigen 4 as a protein scaffold for the generation of novel binding ligands. FEBS Lett. 2000 Jun 23;475(3):225-31.
3 Engineered protein scaffolds for molecular recognition. J Mol Recognit. Jul-Aug 2000;13(4):167-87.
4 Design and expression of soluble CTLA-4 variable domain as a scaffold for the display of functional polypeptides. Proteins. 1999 Aug 1;36(2):217-27.