Details of the PSS

General Information of Protein Scaffold of SBP (PSS) (ID: PS022)
PSS Name
CI2-based binder
Synonyms
Chymotrypsin inhibitor 2-based binder
Diagrammatic Sketch
Highest Status Research
Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Sequence Length 64
Molecular Weight 7 kDa
Parental Protein of This PSS
Parental Protein Name Synonym PDB ID UniProt ID Origin
Chymotrypsin inhibitor 2 CI2; CI-2
1Y1K
A8V3P3
Hordeum vulgare
Synthetic Binding Protein (SBP) Featuring this PSS
SBP Name Highest Status Template Expression System Selection Method Details Ref
CI2-based binder anti-MDM2 CI2-12.1 Research CI2 Mammalian cells N.A.
SBP Info
 		[1]
CI2-based binder anti-Subtilisin-BPN E60A mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN E60S mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN M59R/E60S mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN R62A mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN R65A mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN R67A mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN T58A mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-Subtilisin-BPN T58P mutant Research CI2 Escherichia coli N.A.
SBP Info
 		[2]
CI2-based binder anti-MDM2 CI2-12.1-Ala Research CI2 N.A. N.A.
SBP Info
 		[1]
CI2-based binder anti-MDM2 CI2-Arf37 Research CI2 N.A. N.A.
SBP Info
 		[1]
References
1 Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level. Br J Cancer. 2004 Oct 18;91(8):1488-94
2 Role of the intramolecular hydrogen bond network in the inhibitory power of chymotrypsin inhibitor 2. Biochemistry. 2005 May 10;44(18):6823-30.