General Information of Synthetic Binding Protein (SBP) (ID: SBP000863)
SBP Name
CI2-based binder anti-MDM2 CI2-Arf37
Synonyms
CI2-based binder CI2-Arf37
Molecular Weight 7 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Highest Status Research
Template Name CI2
Protein Scaffold Information of This SBP
Scaffold ID PS022
Scaffold Info
[1]
Scaffold Name CI2-based binder
Scaffold Class Non-Antibody
Fold Type One Alpha-Helix + Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
E3 ubiquitin-protein ligase Mdm2
BTS Info
Binder Research tool N.A. Pharmexa A/S [1]
References
1 Activation of p53 by scaffold-stabilised expression of Mdm2-binding peptides: visualisation of reporter gene induction at the single-cell level. Br J Cancer. 2004 Oct 18;91(8):1488-94