Details of the SBP

General Information of Synthetic Binding Protein (SBP) (ID: SBP003587)
SBP Name
Macrocyclic peptide anti-retromer RT-D1
Synonyms
Macrocyclic peptide RT-D1
Molecular Weight 1.9 kDa
Design Method de novo protein design
Highest Status Research
PDB ID 6XS5
Sequence Length 17
SBP Sequence
>Macrocyclic peptide anti-retromer RT-D1
(AcD)YIIDTPLGVFLSSLKRC
Sequence Description (AcD)Y and Cys from a thioether linkage.
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS044
Scaffold Info
[1]
Scaffold Name Macrocyclic peptide
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Vacuolar protein sorting-associated protein 29-Vacuolar protein sorting-associated protein 35
BTS Info
Inhibitor Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex Kd: 106 nM The University of Queensland [1]
Vacuolar protein sorting-associated protein 35-Vacuolar protein sorting-associated protein 26-Vacuolar protein sorting-associated protein 29
BTS Info
Inhibitor Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex Kd: 130 nM The University of Queensland [1]
Vacuolar protein sorting-associated protein 29
BTS Info
Inhibitor Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex Kd: 95 nM The University of Queensland [1]
References
1 De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Sci Adv. 2021 Dec 3;7(49):eabg4007.