General Information of Binding Target of SBP (BTS) (ID: ST00593)
BTS Name
Vacuolar protein sorting-associated protein 35-Vacuolar protein sorting-associated protein 26-Vacuolar protein sorting-associated protein 29
Synonyms
Vps35-Vps26-Vps29
BTS Type
Protein
Family
VPS35 family;
VPS26 family;
VPS29 family
Organism
Homo sapiens (Human)
UniProt ID
Q96QK1, O75436, Q9UBQ0
UniProt Entry
VPS35_HUMAN, VP26A_HUMAN, VPS29_HUMAN
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Macrocyclic peptide anti-retromer RT-D1 Research Inhibitor Kd: 130 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-D2 Research Inhibitor Kd: 53 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-D3 Research Inhibitor Kd: 25 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-D4 Research Inhibitor N.A. Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-L1 Research Inhibitor Kd: 96 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-L2 Research Inhibitor Kd: 852 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-L3 Research Inhibitor N.A. Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
Macrocyclic peptide anti-retromer RT-L4 Research Inhibitor Kd: 273 nM Tool for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex
SBP Info
[1]
References
1 De novo macrocyclic peptides for inhibiting, stabilizing, and probing the function of the retromer endosomal trafficking complex. Sci Adv. 2021 Dec 3;7(49):eabg4007.