Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00553)
BTS Name	Integrin alpha-IIb-beta-3
BTS Type	Protein
Family	Integrin alpha chain family; Integrin beta chain family
Organism	Homo sapiens (Human)
UniProt ID	P08514, P05106
UniProt Entry	ITA2B_HUMAN, ITB3_HUMAN

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Fab anti-Integrin Abciximab	Research	Binder	Kd: 1.1 nM	Research tool	SBP Info	[1]
Fab anti-Integrin RAD87	Research	Binder	Kd: 3.3 nM	Antithrombotic agents [ICD-11: XM1AM0]	SBP Info	[1]
Fab Tadocizumab	Phase II	Binder	N.A.	Research tool	SBP Info	[2]
Knottin anti-Integrin 2bA	Research	Inhibitor	Kd: 90 nM	Tools as inhibitors of platelet aggregation	SBP Info	[3]
Knottin anti-Integrin 2bJ	Research	Inhibitor	Kd: 60 nM	Tools as inhibitors of platelet aggregation	SBP Info	[3]
Knottin anti-Integrin 2bO	Research	Inhibitor	Kd: 90 nM	Tools as inhibitors of platelet aggregation	SBP Info	[3]
Knottin anti-Integrin b3A	Research	Inhibitor	Kd: 42 nM	Tools as inhibitors of platelet aggregation	SBP Info	[3]
Knottin anti-Integrin b3I	Research	Inhibitor	Kd: 70 nM	Tools as inhibitors of platelet aggregation	SBP Info	[3]
Tendamistat-based binder anti-Integrin variants	Research	Binder	N.A.	Research tool	SBP Info	[4]

References

1	Integrin alphaIIbbeta3-specific synthetic human monoclonal antibodies and HCDR3 peptides that potently inhibit platelet aggregation. FASEB J. 2004 Feb;18(2):361-3.
2	Effect of Treatment With Tabalumab, a B Cell-Activating Factor Inhibitor, on Highly Sensitized Patients With End-Stage Renal Disease Awaiting Transplantation. Am J Transplant. 2016 Apr;16(4):1266-75.
3	Cystine-knot peptides engineered with specificities for (IIb)(3) or (IIb)(3) and (v)(3) integrins are potent inhibitors of platelet aggregation. J Mol Recognit. Jan-Feb 2011;24(1):127-35.
4	Use of phage display to probe the evolution of binding specificity and affinity in integrins. Protein Eng. 2003 Jan;16(1):65-72.