Details of the BTS | SYNBIP

General Information of Binding Target of SBP (BTS) (ID: ST00523)
BTS Name	Testosterone
Synonyms	Testosterone
BTS Type	Small Molecule
Organism	Homo sapiens (Human)

Synthetic Binding Protein (SBP) Targeting This BTS

SBP Name	Highest Status	Mechanism	Affinity	Application	Details	Ref
Affilin anti-Estradiol/Testosterone SPC-4-10	Research	Binder	Kd: 138 nM	Research tool	SBP Info	[1]
Affilin anti-Estradiol/Testosterone SPC-4-B6	Research	Binder	Kd: 145 nM	Research tool	SBP Info	[1]
Fab anti-Testosterone A58	Research	Binder	N.A.	Tools for in the complex assay medium containing human serum	SBP Info	[2]
Fab anti-Testosterone A60	Research	Binder	N.A.	Tools for in the complex assay medium containing human serum	SBP Info	[2]
Fab anti-Testosterone clone 77	Research	Binder	Kd: 0.3 nM	Research tool	SBP Info	[3]
Fab anti-Testosterone HCDR1 2B5	Research	Binder	N.A.	Research tool	SBP Info	[2]
Fab anti-Testosterone LCDR2 1D7	Research	Binder	N.A.	Research tool	SBP Info	[2]
Neocarzinostatin-based binder anti-Testosterone NCS-1a.15	Research	Inhibitor	Kd: 14800 nM	Research tool	SBP Info	[4], [5]
Neocarzinostatin-based binder anti-Testosterone NCS-1b.6	Research	Inhibitor	Kd: 6900 nM	Research tool	SBP Info	[4], [5]
Neocarzinostatin-based binder anti-Testosterone NCS-3.24	Research	Inhibitor	Kd: 13000 nM	Research tool	SBP Info	[4], [5]
Neocarzinostatin-based binder anti-Testosterone NCS-4.1	Research	Inhibitor	Kd: 55000 nM	Research tool	SBP Info	[4], [5]
Neocarzinostatin-based binder anti-Testosterone NCS-4.4	Research	Inhibitor	Kd: 18100 nM	Research tool	SBP Info	[4], [5]
Neocarzinostatin-based binder anti-Testosterone NCS-A6	Research	Binder	N.A.	Cancers [ICD-11: 2D4Z]	SBP Info	[6]
Neocarzinostatin-based binder anti-Testosterone NCS-C7	Research	Binder	N.A.	Cancers [ICD-11: 2D4Z]	SBP Info	[6]
Neocarzinostatin-based binder anti-Testosterone NCS-C8	Research	Binder	N.A.	Cancers [ICD-11: 2D4Z]	SBP Info	[6]
Neocarzinostatin-based binder anti-Testosterone NCS-E8	Research	Binder	N.A.	Cancers [ICD-11: 2D4Z]	SBP Info	[6]

References

1	Affilin-novel binding molecules based on human gamma-B-crystallin, an all beta-sheet protein. J Mol Biol. 2007 Sep 7;372(1):172-85.
2	Fine tuning of an anti-testosterone antibody binding site by stepwise optimisation of the CDRs. Immunotechnology. 1998 Jun;4(1):59-69.
3	Crystal structure of an in vitro affinity- and specificity-matured anti-testosterone Fab in complex with testosterone. Improved affinity results from small structural changes within the variable domains. J Biol Chem. 2002 Nov 15;277(46):44021-7.
4	Structures of in vitro evolved binding sites on neocarzinostatin scaffold reveal unanticipated evolutionary pathways. J Mol Biol. 2006 Apr 28;358(2):455-71.
5	In vitro evolution of the binding specificity of neocarzinostatin, an enediyne-binding chromoprotein. Biochemistry. 2003 May 20;42(19):5674-83.
6	Disulfide bond substitution by directed evolution in an engineered binding protein. Chembiochem. 2009 May 25;10(8):1349-59.