Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00457)
BTS Name
Hepatitis C virus internal ribosomal entry site RNA
Synonyms
HCV IRES RNA
BTS Type
RNA
Organism
Hepatitis C virus (HCV)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Fab anti-IRES HCV2 Research binder Kd: 32 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[1]
Fab anti-IRES HCV3 Research binder Kd: 37 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[1]
Fab anti-IRES V1 Research binder N.A. Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[2]
Fab anti-IRES V39 Research binder N.A. Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[2]
Fab anti-IRES V4 Research binder N.A. Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[2]
Peptide aptamer anti-HCV 6B48 Research Inhibitor Kd: 17.5 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[3], [4]
Peptide aptamer anti-HCV 6B48C Research Inhibitor Kd: 3.7 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[3], [4]
Peptide aptamer anti-HCV 6B4C Research Inhibitor Kd: 0.7 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[3], [4]
Peptide aptamer anti-HCV linear 6B4 Research Inhibitor Kd: 6.5 nM Hepatitis C virus infection [ICD-11: XN1EZ]
SBP Info
 		[3], [4]
References
1 Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. ACS Chem Biol. 2020 Jan 17;15(1):205-216.
2 Antibody designing against IIIabc junction (JIIIabc) of HCV IRES through affinity maturation; RNA-Antibody docking and interaction analysis. PLoS One. 2023 Sep 8;18(9):e0291213.
3 Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15293-8.
4 Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.