Details of the SBP | SYNBIP

General Information of Synthetic Binding Protein (SBP) (ID: SBP000190)
SBP Name	Peptide aptamer anti-HCV 6B4C
Synonyms	Peptide aptamer 6B4C
Design Method	Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method	mRNA display
Highest Status	Research

Protein Scaffold Information of This SBP
Scaffold ID	PS051 Scaffold Info					[1] , [2]
Scaffold Name	Peptide aptamer
Scaffold Class	Non-Antibody
Fold Type	Alpha-Helices + Beta-Sheets + Loops

Binding Target(s) of This SBP (BTS)

BTS Name	Details	Mechanism	Application	Affinity	Research Organization	Ref
Hepatitis C virus internal ribosomal entry site RNA	BTS Info	Inhibitor	Hepatitis C virus infection [ICD-11: XN1EZ]	Kd: 0.7 nM	Massachusetts General Hospital	[1] , [2]

References

1	Selection of cyclic peptide aptamers to HCV IRES RNA using mRNA display. Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15293-8.
2	Peptide aptamers with biological and therapeutic applications. Curr Med Chem. 2011;18(27):4215-22.