Details of the SBP
| General Information of Synthetic Binding Protein (SBP) (ID: SBP003628) | ||||||
|---|---|---|---|---|---|---|
| SBP Name |
Fab anti-IRES HCV3
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| Synonyms |
Fab HCV3
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| Molecular Weight | 48 kDa | |||||
| Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
| Selection Method | Phage Library | |||||
| Highest Status | Research | |||||
| PDB ID | 6U8K | |||||
| Sequence Length | 447 | |||||
| SBP Sequence |
>Heavy chain
EISEVQLVESGGGLVQPGGSLRLSCAASGFYISYSSIHWVRQAPGKGLEWVASISPSSGS TYYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSRYSRYRRGFDYWGQGTLV TVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAV LQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT >Light chain SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVP SRFSGSRSGTDFTLTISSLQPEDFATYYCQQYSSSPYTFGQGTKVEIKRTVAAPSVFIFP PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTL TLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
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| 3D Structure | ||||||
| Experimentally Validated Structure | ||||||
| Click to Save PDB File | ||||||
| Protein Scaffold Information of This SBP | ||||||
|---|---|---|---|---|---|---|
| Scaffold ID | PS034 | [1] | ||||
| Scaffold Name | Fab | |||||
| Scaffold Class | Antibody fragment | |||||
| Fold Type | Beta-Sheets + Loops | |||||
| Binding Target(s) of This SBP (BTS) |
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| BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
|---|---|---|---|---|---|---|
| Hepatitis C virus internal ribosomal entry site RNA | binder | Hepatitis C virus infection [ICD-11: XN1EZ] | Kd: 37 nM | University of Chicago | [1] | |