Details of the BTS

General Information of Binding Target of SBP (BTS) (ID: ST00349)
BTS Name
Fc receptor
Synonyms
FcRn
BTS Type
Protein
Organism
Homo sapiens (Human)
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Abdurin anti-EphA2/FcRn B11 Research Binder N.A. Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Abdurin anti-EphA2/FcRn B6 Research Binder N.A. Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Abdurin anti-EphA2/FcRn D2 Research Binder N.A. Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Abdurin anti-EphA2/FcRn G7 Research Binder N.A. Tumors [ICD-11: XH1N44]
SBP Info
 		[1]
Affibody anti-FcRn/FcRn Z(FcRn_16) Research Binder Kd: 14 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody anti-FcRn/FcRn Z(FcRn_16) Research Binder Kd: >500 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody anti-FcRn/FcRn Z(FcRn_2) Research Binder Kd: 12 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody anti-FcRn/FcRn Z(FcRn_2) Research Binder Kd: >500 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody anti-FcRn/FcRn Z(FcRn_4) Research Binder Kd: 50 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody anti-FcRn/FcRn Z(FcRn_4) Research Binder Kd: >1000 nM Tools for extending circulatory half-life
SBP Info
 		[2]
Affibody Tifalibep Phase I; Discontinued Inhibitor N.A. Antibody (IgG) mediated autoimmune
SBP Info
 		[3]
I-body AD-214 Phase I Binder N.A. Fibrosis [ICD-11: CA25.Z]
SBP Info
 		[4]
References
1 High Affinity Binders to EphA2 Isolated from Abdurin Scaffold Libraries; Characterization, Binding and Tumor Targeting. PLoS One. 2015 Aug 27;10(8):e0135278.
2 An engineered affibody molecule with pH-dependent binding to FcRn mediates extended circulatory half-life of a fusion protein. Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17110-5.
3 AffibodyAB. Product Development Pipeline. 2021.
4 AdAlta. Product Development Pipeline. 2021.