General Information of Binding Target of SBP (BTS) (ID: ST00208)
BTS Name
Signal transducer and activator of transcription 3
Synonyms
Acute-phase response factor
BTS Type
Protein
Family
Transcription factor STAT family
Gene Name
STAT3
Organism
Homo sapiens (Human)
Function
Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4 Upon activation of IL6ST/gp130 signaling by interleukin-6 (IL6), binds to the IL6-responsive elements identified in the promoters of various acute-phase protein genes Activated by IL31 through IL31RA Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3, leads to disrupt STAT3 dimerization and inhibit its transcription activity Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity Plays a crucial role in basal beta cell functions, such as regulation of insulin secretion (By similarity).
UniProt ID
P40763
UniProt Entry
STAT3_HUMAN
PFam
PF00017 ; PF01017 ; PF02864 ; PF02865
Gene ID
6774
Sequence
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNL
LGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAA
TAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLK
SQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEEL
ADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQ
HRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNY
QLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGN
GGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWY
NMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYS
GCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILST
KPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIM
DATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSN
TIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMELTSECATSPM
Sequence Length
770
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-STAT3 MS3-1 Research Inhibitor Kd: 127 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-2 Research Inhibitor Kd: 104 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-4 Research Inhibitor Kd: 18 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-5 Research Inhibitor Kd: 88 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-N1 Research Inhibitor Kd: 65 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-N3 Research Inhibitor Kd: 40 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Monobody anti-STAT3 MS3-N5 Research Inhibitor Kd: 39 nM Cancers [ICD-11: 2D4Z]
SBP Info
[1]
Peptide aptamer anti-STAT3 rS3-PA Research Inhibitor N.A. Tumors [ICD-11: XH1N44]
SBP Info
[2]
References
1 Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains. Nat Commun. 2020 Aug 17;11(1):4115.
2 Increasing the range of drug targets: interacting peptides provide leads for the development of oncoprotein inhibitors. Bioengineered. Nov-Dec 2012;3(6):320-5.