Details of the SBP
General Information of Synthetic Binding Protein (SBP) (ID: SBP001252) | ||||||
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SBP Name |
Monobody anti-STAT3 MS3-4
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Synonyms |
MS3-4
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Molecular Weight | 10.3 kDa | |||||
Design Method | Traditional methods (Site-directed mutagenesis and/or Directed evolution) | |||||
Expression System | A549 cells | |||||
Highest Status | Research | |||||
Sequence Length | 95 | |||||
SBP Sequence |
>Monobody anti-STAT3 MS3-4
VSSVPTKLEVVAATPTSLLISWDAPAVTVDFYFITYGETGGNSPVQEFTVPGSKSTATIS GLKPGVDYTITVYAWSDYYPLYWEGSSSPISIYRT |
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3D Structure | ||||||
Computationally Modelled Structure | ||||||
Click to Save PDB File | ||||||
Template Name | 10th domain of fibronectin type III (10Fn3) | |||||
Template Sequence Description | X denotes a mixture of 30% Tyr, 15% Ser, 10% Gly, 5% Phe, 5% Trp, and 2.5% each of all the other amino acids except for Cys; O denotes a mixture of Asn, Asp, His, Ile, Leu, Phe, Tyr, and Val; U denotes a mixture of His, Leu, Phe, and Tyr; Z denotes a mixture of Ala, Glu, Lys, and Thr. | |||||
Protein Scaffold Information of This SBP | ||||||
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Scaffold ID | PS047 | [1] | ||||
Scaffold Name | Monobody | |||||
Scaffold Class | Non-Antibody | |||||
Fold Type | Beta-Sheets + Loops | |||||
Binding Target(s) of This SBP (BTS) |
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BTS Name | Details | Mechanism | Application | Affinity | Research Organization | Ref |
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Signal transducer and activator of transcription 3 | Inhibitor | Cancers [ICD-11: 2D4Z] | Kd: 18 nM | Swiss Institute for Experimental Cancer Research (ISREC) | [1] | |