Details of the BTS
| General Information of Binding Target of SBP (BTS) (ID: ST00203) | ||||||
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| BTS Name |
Adhesion G-protein coupled receptor G1
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| Synonyms |
G-protein coupled receptor 56; Serpentine receptor cyt28
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| BTS Type |
Protein
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| Family |
G-protein coupled receptor 2 family;
LN-TM7 subfamily |
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| Gene Name |
Adgrg1
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| Organism |
Mus musculus (Mouse)
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| Function |
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 (By similarity). Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche Plays a critical role in tumourigenesis (By similarity). Plays essential role in testis development
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| UniProt ID | ||||||
| UniProt Entry | ||||||
| PFam | ||||||
| Gene ID | ||||||
| Sequence |
MAVQVLRQMVYFLLSLFSLVQGAHSGSPREDFRFCGQRNQTQQSTLHYDQSSEPHIFVWN
TEETLTIRAPFLAAPDIPRFFPEPRGLYHFCLYWSRHTGRLHLRYGKHDYLLSSQASRLL CFQKQEQSLKQGAPLIATSVSSWQIPQNTSLPGAPSFIFSFHNAPHKVSHNASVDMCDLK KELQQLSRYLQHPQKAAKRPTAAFISQQLQSLESKLTSVSFLGDTLSFEEDRVNATVWKL PPTAGLEDLHIHSQKEEEQSEVQAYSLLLPRAVFQQTRGRRRDDAKRLLVVDFSSQALFQ DKNSSQVLGEKVLGIVVQNTKVTNLSDPVVLTFQHQPQPKNVTLQCVFWVEDPASSSTGS WSSAGCETVSRDTQTSCLCNHLTYFAVLMVSSTEVEATHKHYLTLLSYVGCVISALACVF TIAAYLCSRRKSRDYTIKVHMNLLSAVFLLDVSFLLSEPVALTGSEAACRTSAMFLHFSL LACLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSIVGWGFPVFLVTLVALVDVNNYGPII LAVRRTPERVTYPSMCWIRDSLVSYVTNLGLFSLVFLFNLAMLATMVVQILRLRPHSQNW PHVLTLLGLSLVLGLPWALVFFSFASGTFQLVILYLFSIITSFQGFLIFLWYWSMRFQAQ GGPSPLKNNSDSAKLPISSGSTSSSRI |
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| Sequence Length |
687
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| Synthetic Binding Protein (SBP) Targeting This BTS |
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| SBP Name | Highest Status | Mechanism | Affinity | Application | Details | Ref |
|---|---|---|---|---|---|---|
| Monobody anti-GPR56 clone beta10 | Research | Binder | N.A. | aGPCR-targeted therapeutics | [1] | |
| Monobody anti-GPR56 clone beta11 | Research | Binder | N.A. | aGPCR-targeted therapeutics | [1] | |
| Monobody anti-GPR56 clone beta12 | Research | Binder | Kd: 5.6 nM | aGPCR-targeted therapeutics | [2], [1] | |
| Monobody anti-GPR56 clone beta13 | Research | Binder | N.A. | aGPCR-targeted therapeutics | [1] | |
| Monobody anti-GPR56 clone beta15 | Research | Binder | N.A. | aGPCR-targeted therapeutics | [1] | |
| Monobody anti-GPR56 clone beta17 | Research | Binder | N.A. | aGPCR-targeted therapeutics | [1] | |
| Monobody anti-GPR56 clone beta3 | Research | Binder | Kd: 130 nM | aGPCR-targeted therapeutics | [2], [1] | |
| References |
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