General Information of Binding Target of SBP (BTS) (ID: ST00195)
BTS Name
Adhesion G-protein coupled receptor G1
Synonyms
G-protein coupled receptor 56; Protein TM7XN1
BTS Type
Protein
Family
G-protein coupled receptor 2 family;
LN-TM7 subfamily
Gene Name
ADGRG1
Organism
Homo sapiens (Human)
Function
Receptor involved in cell adhesion and probably in cell-cell interactions. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Receptor for collagen III/COL3A1 in the developing brain and involved in regulation of cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination (By similarity). Binding to the COL3A1 ligand inhibits neuronal migration and activates the RhoA pathway by coupling to GNA13 and possibly GNA12 Plays a role in the maintenance of hematopoietic stem cells and/or leukemia stem cells in bone marrow niche (By similarity). Plays a critical role in cancer progression by inhibiting VEGFA production threreby inhibiting angiogenesis through a signaling pathway mediated by PRKCA Plays an essential role in testis development (By similarity).; [ADGRG1 N-terminal fragment]: Plays a critical role in cancer progression by activating VEGFA production and angiogenesis through a signaling pathway mediated by PRKCA
UniProt ID
Q9Y653
UniProt Entry
AGRG1_HUMAN
PFam
PF00002 ; PF18619 ; PF01825 ; PF18587
Gene ID
9289
Sequence
MTPQSLLQTTLFLLSLLFLVQGAHGRGHREDFRFCSQRNQTHRSSLHYKPTPDLRISIEN
SEEALTVHAPFPAAHPASRSFPDPRGLYHFCLYWNRHAGRLHLLYGKRDFLLSDKASSLL
CFQHQEESLAQGPPLLATSVTSWWSPQNISLPSAASFTFSFHSPPHTAAHNASVDMCELK
RDLQLLSQFLKHPQKASRRPSAAPASQQLQSLESKLTSVRFMGDMVSFEEDRINATVWKL
QPTAGLQDLHIHSRQEEEQSEIMEYSVLLPRTLFQRTKGRSGEAEKRLLLVDFSSQALFQ
DKNSSQVLGEKVLGIVVQNTKVANLTEPVVLTFQHQLQPKNVTLQCVFWVEDPTLSSPGH
WSSAGCETVRRETQTSCFCNHLTYFAVLMVSSVEVDAVHKHYLSLLSYVGCVVSALACLV
TIAAYLCSRVPLPCRRKPRDYTIKVHMNLLLAVFLLDTSFLLSEPVALTGSEAGCRASAI
FLHFSLLTCLSWMGLEGYNLYRLVVEVFGTYVPGYLLKLSAMGWGFPIFLVTLVALVDVD
NYGPIILAVHRTPEGVIYPSMCWIRDSLVSYITNLGLFSLVFLFNMAMLATMVVQILRLR
PHTQKWSHVLTLLGLSLVLGLPWALIFFSFASGTFQLVVLYLFSIITSFQGFLIFIWYWS
MRLQARGGPSPLKSNSDSARLPISSGSTSSSRI
Sequence Length
693
Synthetic Binding Protein (SBP) Targeting This BTS
SBP Name Highest Status Mechanism Affinity Application Details Ref
Monobody anti-GPR56 Alpha5 Research Agonist Kd: 1.8 nM Tools for oligodendrocyte development
SBP Info
[1]
Monobody anti-GPR56 clone beta1 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta14 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta16 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta18 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta19 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta2 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta3 Research Binder Kd: 9.6 nM aGPCR-targeted therapeutics
SBP Info
[3], [2]
Monobody anti-GPR56 clone beta4 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta5 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta6 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta7 Research Agonist Kd: 66.7 nM aGPCR-targeted therapeutics
SBP Info
[3], [2]
Monobody anti-GPR56 clone beta7 Research Agonist Kd: 4 nM aGPCR-targeted therapeutics
SBP Info
[3], [2]
Monobody anti-GPR56 clone beta8 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
Monobody anti-GPR56 clone beta9 Research Binder N.A. aGPCR-targeted therapeutics
SBP Info
[2]
References
1 Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21;91(6):1292-1304.
2 Stachel-independent modulation of GPR56/ADGRG1 signaling by synthetic ligands directed to its extracellular region. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):10095-10100.
3 Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands. Sci Rep. 2020 Oct 9;10(1):16912.