General Information of Synthetic Binding Protein (SBP) (ID: SBP001208)
SBP Name
Monobody anti-GPR56 Alpha5
Synonyms
Monobody Alpha5
Molecular Weight 10.4 kDa
Design Method Traditional methods (Site-directed mutagenesis and/or Directed evolution)
Selection Method Yeast display
Highest Status Research
PDB ID 5KVM
Sequence Length 95
SBP Sequence
>Monobody anti-GPR56 Alpha5
SVPTKLEVVAATPTSLLISWDAPAVTVDHYVITYGETGGSPWSWQEFEVPGSKSTATISG
LKPGVDYTITVYASSFDWTIFPNYYSSPISINYRT
3D Structure
Experimentally Validated Structure
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Protein Scaffold Information of This SBP
Scaffold ID PS047
Scaffold Info
[1]
Scaffold Name Monobody
Scaffold Class Non-Antibody
Fold Type Beta-Sheets + Loops
Binding Target(s) of This SBP (BTS)
BTS Name Details Mechanism Application Affinity Research Organization Ref
Adhesion G-protein coupled receptor G1
BTS Info
Agonist Tools for oligodendrocyte development Kd: 1.8 nM University of Chicago [1]
References
1 Structural Basis for Regulation of GPR56/ADGRG1 by Its Alternatively Spliced Extracellular Domains. Neuron. 2016 Sep 21;91(6):1292-1304.